科研资料整理

新浪网本报讯 （记者 童思娜 通讯员
P影妍）春节历经千辛万苦回到熟悉的故乡，可是身体反而会不适，易出现腹泻、感冒、精神疲乏、食欲不振，甚至心慌胸闷、长暗疮等俗称为“水土不服”的症
状。医生介绍，回乡水土不服不妨喝点蜂蜜，它有提高免疫力，抗疲劳，促进消化，改善睡眠，保护心血管等作用，可帮助归家游子度过回乡头几天出现的不适症
状。

　　生活环境突然改变易不适

　　市中医院罗文峰副主任医师认为，回乡出现各种不适症状，是自身适应环境的能力未能及时调整过来，在新环境中没有达到平衡与和谐所致，而且这种不适与地域跨度、生活习惯及城乡差异成正比。

　　人体健康与周围环境有着密切关系，长途跋涉的疲累已让机体免疫功能下降，同时人体暂时不能适应气候、水质、饮食等生活环境的突然改变，就会产生一系列不适症状，其中以肠道菌群紊乱而引起的腹泻最为常见。而蜂蜜可说是一味治疗水土不服的良药。

　　蜂蜜可迅速除疲劳促睡眠

　　蜂蜜清香甘甜，容易被吸收和消化。从中医角度看，腹泻多是饮食不节、脾胃虚弱所致，而蜂蜜有和中健胃、润肠通便的功效，可有效地调节胃肠道功
能，增进肠蠕动，既有助消化，又可防止腹泻。蜂蜜中含有的酶类和矿物质可提高人体免疫力，葡萄糖、维生素以及磷、钙等物质则有镇静安神的作用，可迅速消除
疲劳，促进睡眠。此外，蜂蜜对咽炎、支气管炎也有辅助疗效。

　　医生建议，蜂蜜适宜晚上临睡前或是早上空腹喝。冲泡蜂蜜时不要用刚煮沸的开水，否则会破坏蜂蜜的营养功效，用温水冲泡并搅匀就可以了。

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Biochim Biophys Acta. 2007 Jul;1770(7):1021-7. Epub 2007 Mar 15.

Pancreatic adenocarcinoma is characterized by a poor prognosis and lack of response to conventional therapy. The purpose of this study was to investigate the effects of triptolide (TL) on proliferation and apoptosis of pancreatic cancer cells in vitro. We found that TL induced prominent growth inhibition and apoptosis in human pancreatic cell lines. In addition, TL treatment significantly down-regulated 5-lipoxygenase (5-LOX) expression, as well as downstream leukotriene B4 (LTB4) production, in these cell lines. Furthermore, overexpression of 5-LOX in SW1990 cell lines or exogenous LTB4 made them more resistant to TL-induced apoptosis, which was correlated with increased Bcl-2 expression. Taken together, these findings suggest that inhibition of the 5-LOX pathway of arachidonic acid metabolism is associated with the anti-proliferation activity of TL. We also provide evidence that TL has clinical therapeutic value for patients with pancreatic cancer

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Hepatology. 1993 Dec;18(6):1483-9

Cytochrome P-450 2E1 is a specific isozyme of cytochrome P-450 induced by ethanol. P-450 2E1 may also be the only enzyme that metabolizes N-nitrosodimethylamine at a very low concentration. Because N-nitrosodimethylamine is a procarcinogen, the possibility that induction of P-450 2E1 by alcohol abuse may accelerate the carcinogenic action of a very small dose of N-nitrosodimethylamine should be considered. To investigate this possibility, effects of ethanol on the hepatic carcinogenic action of a very small dose of N-nitrosodimethylamine were analyzed in rats. Sixty Wistar male rats were divided into two groups (ethanol and control) according to the liquid diets they were fed. After preliminary feeding, N-nitrosodimethylamine in two concentrations (1.5 ng/ml and 3.0 micrograms/ml) in drinking water was given with the diets for 40 or 60 wk. To avoid metabolic competition between ethanol and n-nitrosodimethylamine, we gave N-nitrosodimethylamine and the diets alternately. The average amount of N-nitrosodimethylamine consumed per day was 11 to 37 ng/kg body weight in the 1.5-ng group and was 27 to 37 micrograms/kg body weight in the 3.0-microgram group. Hepatic P-450 2E1 content was six times higher in the ethanol-treated groups than in the control groups throughout the experiment. Visible nodules and enzyme-altered foci were not found in rats in any group at the end of the fortieth week. These preneoplastic changes were found at the end of the sixtieth week only in rats in the groups treated with both ethanol and N-nitrosodimethylamine

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Environ Mol Mutagen. 2000;36(2):97-104.Click here to read

A cDNA coding for rat cytochrome P450 2E1 was cloned into the multicopy vector pYeDP60 and expressed in haploid RSY6 and diploid RS112 yeast strains of Saccharomyces cerevisiae under control of the GAL10-CYC1 promoter. Spectral and catalytic properties of the expressed 2E1 were examined in whole cells or microsomes of both strains. The level of CYP2E1 obtained in RS112 (200 pmol/mg microsomal protein) was the highest among CYP2E1 produced in the various expression systems. The monooxygenase activity in the microsomes of both strains, measured as aniline hydroxylase, was found comparable to that of control rat hepatic microsomes. In a reconstituted system in the presence of exogenous rat P450 reductase, their activity increased about 10-fold. When exposed to the carcinogen NDMA, a known 2E1 substrate, the recombination frequency determined in the 2E1-expressing RS112 cells was enhanced, in a dose-dependent manner, up to 20-fold. The exposure of the same cells to the hepatotoxic solvents, N-methyl- and N-ethylformamide, resulted in an induction of recombination frequency, which was not observed in the void plasmid containing RS112 cells in the presence of S9 hepatic fractions from pyrazole-induced rats, as a specific exogenous metabolic activation system. These results demonstrate that the 2E1-expressing cells metabolize the two N-alkylformamides to genotoxic intermediates and, therefore, they provide an useful tool to study the bioactivation mechanism of potential P450 2E1 substrates.

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