Cytochrome P4502E1 sensitizes to tumor necrosis factor alpha-induced liver injury through activation of mitogen-activated protein kinases in mice
Conclusion: These results show that CYP2E1 sensitizes liver hepatocytes to LPS or TNF- and that the CYP2E1-enhanced LPS or TNF- injury, oxidant stress, and mitochondrial injury is JNK or p38 MAPK dependent. (HEPATOLOGY 2008.)
and that the CYP2E1-enhanced LPS or TNF-